紫杉醇（泰素）诱导小鼠巨噬细胞杀伤硕大利什曼原虫。
Paclitaxel (Taxol)-induced killing of Leishmania major in murine macrophages.
作者信息
Doherty T M, Sher A, Vogel S N
机构信息
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
出版信息
Infect Immun. 1998 Sep;66(9):4553-6. doi: 10.1128/IAI.66.9.4553-4556.1998.
Abstract
The antitumor drug paclitaxel (Taxol) has been demonstrated to be a lipopolysaccharide mimetic in murine macrophages. In this study, the capacity of paclitaxel to activate macrophages to become microbicidal for Leishmania major was examined. Paclitaxel and gamma interferon synergized to kill intracellular L. major in Lpsn, but not Lpsd, macrophages by a nitric oxide (NO.)-dependent mechanism.
摘要
抗肿瘤药物紫杉醇（泰素）已被证明在小鼠巨噬细胞中具有脂多糖模拟物的作用。在本研究中，检测了紫杉醇激活巨噬细胞对杜氏利什曼原虫产生杀菌作用的能力。紫杉醇和γ干扰素协同作用，通过一氧化氮（NO.）依赖性机制杀死Lpsn巨噬细胞内的杜氏利什曼原虫，但对Lpsd巨噬细胞无效。
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本文引用的文献
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2
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J Immunol. 1998 Jun 1;160(11):5506-13.
3
Effects of paclitaxel on cytokine synthesis by unprimed human monocytes, T lymphocytes, and breast cancer cells.紫杉醇对未致敏的人单核细胞、T淋巴细胞及乳腺癌细胞细胞因子合成的影响。
Cancer Immunol Immunother. 1998 Apr;46(2):104-12. doi: 10.1007/s002620050468.
4
Leishmania major: effect of infectious dose on T cell subset development in BALB/c mice.硕大利什曼原虫：感染剂量对BALB/c小鼠T细胞亚群发育的影响
Exp Parasitol. 1996 Nov;84(2):124-35. doi: 10.1006/expr.1996.0098.
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Biochem Biophys Res Commun. 1996 Oct 3;227(1):227-35. doi: 10.1006/bbrc.1996.1494.
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Paclitaxel (Taxol)-induced NF-kappaB translocation in murine macrophages.紫杉醇（泰素）诱导小鼠巨噬细胞中核因子κB的易位。
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J Clin Invest. 1994 Jul;94(1):413-7. doi: 10.1172/JCI117338.
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