Genetics and respiratory disease. 2. Alpha 1-antitrypsin deficiency, cirrhosis and emphysema.
作者信息
Mahadeva R, Lomas D A
机构信息
Department of Medicine, University of Cambridge, MRC Centre, UK.
出版信息
Thorax. 1998 Jun;53(6):501-5. doi: 10.1136/thx.53.6.501.
Abstract
摘要
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本文引用的文献
1
Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation.野生型α1-抗胰蛋白酶处于典型的抑制构象。
J Mol Biol. 1998 Jan 23;275(3):419-25. doi: 10.1006/jmbi.1997.1458.
2
Conformational disease.构象病
Lancet. 1997 Jul 12;350(9071):134-8. doi: 10.1016/S0140-6736(97)02073-4.
3
Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats.维甲酸治疗可消除弹性蛋白酶诱导的大鼠肺气肿。
Nat Med. 1997 Jun;3(6):675-7. doi: 10.1038/nm0697-675.
4
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved alpha1-antitrypsin at 2.7 A.丝氨酸蛋白酶抑制剂疏水核心和柔性反应环中的天然菌株：2.7埃下未切割的α1-抗胰蛋白酶的晶体结构。
Structure. 1996 Oct 15;4(10):1181-92. doi: 10.1016/s0969-2126(96)00126-8.
5
Structural explanation for the deficiency of S alpha 1-antitrypsin.α1-抗胰蛋白酶缺乏的结构解释。
Nat Struct Biol. 1996 Nov;3(11):910-1. doi: 10.1038/nsb1196-910.
6
Inhibitory conformation of the reactive loop of alpha 1-antitrypsin.α1-抗胰蛋白酶反应环的抑制构象
Nat Struct Biol. 1996 Aug;3(8):676-81. doi: 10.1038/nsb0896-676.
7
C-antineutrophil cytoplasmic antibody positivity in vasculitis patients is associated with the Z allele of alpha-1-antitrypsin, and P-antineutrophil cytoplasmic antibody positivity with the S allele.血管炎患者中抗中性粒细胞胞浆抗体阳性与α-1抗胰蛋白酶的Z等位基因相关，而抗蛋白酶3抗中性粒细胞胞浆抗体阳性与S等位基因相关。
Nephrol Dial Transplant. 1996 Mar;11(3):438-43.
8
The endoplasmic reticulum degradation pathway for mutant secretory proteins alpha1-antitrypsin Z and S is distinct from that for an unassembled membrane protein.突变型分泌蛋白α1-抗胰蛋白酶Z和S的内质网降解途径与未组装膜蛋白的内质网降解途径不同。
J Biol Chem. 1996 May 31;271(22):13215-20. doi: 10.1074/jbc.271.22.13215.
9
Alpha 1-antitrypsin deficiency: evaluation of bronchiectasis with CT.α1抗胰蛋白酶缺乏症：CT评估支气管扩张
Radiology. 1996 Apr;199(1):137-41. doi: 10.1148/radiology.199.1.8633137.
10
Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin.Z突变对α1-抗胰蛋白酶物理性质和抑制特性的影响。
Biochemistry. 1993 Jan 19;32(2):500-8. doi: 10.1021/bi00053a014.
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