Norman R W, Scurr D S, Robertson W G, Peacock M
Br J Urol. 1984 Dec;56(6):594-8. doi: 10.1111/j.1464-410x.1984.tb06124.x.
In vitro studies showed that sodium pentosan polysulphate (SPP) is an active inhibitor of calcium oxalate (CaOx) crystal growth and agglomeration and that it acts by increasing the negative zeta potential on the surface of CaOx crystals. Oral administration of SPP to control subjects, recurrent stone formers and patients with primary hyperoxaluria resulted in an overall increase of 8% (P less than 0.01) in the polyanionic inhibition of CaOx crystallisation in urine as measured by the zeta potential. SPP could provide a novel approach to the medical prevention of recurrent CaOx stone disease.
体外研究表明，戊聚糖多硫酸酯钠（SPP）是草酸钙（CaOx）晶体生长和聚集的活性抑制剂，其作用机制是增加CaOx晶体表面的负ζ电位。对健康受试者、复发性结石形成者和原发性高草酸尿症患者口服SPP后，通过ζ电位测量发现，尿液中CaOx结晶的多阴离子抑制作用总体增加了8%（P<0.01）。SPP可能为复发性CaOx结石病的医学预防提供一种新方法。
