Suppr超能文献

一名64岁男性的贲门失弛缓症。

Achalasia in a sixty-four-year-old man.

作者信息

Komisaruk E A, Seymour N E

机构信息

Yale-New Haven Hospital, Connecticut, USA.

出版信息

Yale J Biol Med. 1998 Jan-Feb;71(1):23-30.

Abstract

Achalasia is an esophageal motility disorder characterized by increased lower esophageal sphincter pressure and absence of peristalsis in the lower esophagus. Patients typically present with complaints of progressive difficulty swallowing over a period of several years. Diagnosis is confirmed by esophageal manometry. Complications of achalasia include esophagitis, aspiration and possibly an increased risk of esophageal carcinoma. Medical treatment options include pneumatic dilatation, esophageal bougienage, nitrates, calcium channel blockers and botulinum toxin injections. The primary method of surgical treatment is the Heller myotomy, in which longitudinal incisions are made in the muscle fibers of the lower esophageal sphincter to reduce sphincter pressure. Frequently, a fundoplication is performed in addition to the myotomy to decrease the likelihood of development of gastroesophageal reflux. In recent years, the Heller myotomy has been performed both thoracoscopically and laparoscopically. An additional development has been the placement of an endoscope in the esophagus to provide transillumination during surgery; intraoperative endoscopy allows improved assessment of the depth of myotomy incisions and reduces the risk of esophageal perforation. The case report below describes a 64-year-old-man with achalasia who presented with persistent dysphagia despite multiple attempts at medical treatment. A laparoscopic Heller myotomy with Toupet fundoplication was performed with subsequent eradication of symptoms. A discussion of the epidemiology, etiology, clinical presentation, diagnosis and treatment of achalasia follows the case report.

摘要

贲门失弛缓症是一种食管动力障碍性疾病,其特征为食管下括约肌压力升高以及食管下段蠕动消失。患者通常会诉说在数年时间里吞咽困难逐渐加重。通过食管测压可确诊。贲门失弛缓症的并发症包括食管炎、误吸,以及食管癌风险可能增加。药物治疗选择包括气囊扩张、食管探条扩张、硝酸盐类、钙通道阻滞剂和肉毒杆菌毒素注射。外科治疗的主要方法是赫勒肌切开术,即在食管下括约肌的肌纤维上做纵向切口以降低括约肌压力。通常,除肌切开术外还会进行胃底折叠术,以降低发生胃食管反流的可能性。近年来,赫勒肌切开术已通过胸腔镜和腹腔镜进行。另外一个进展是在食管内放置内窥镜以在手术期间提供透照;术中内窥镜检查可更好地评估肌切开术切口的深度,并降低食管穿孔的风险。以下病例报告描述了一名64岁患有贲门失弛缓症的男性,尽管多次尝试药物治疗仍存在持续性吞咽困难。实施了腹腔镜下赫勒肌切开术加 Toupet 胃底折叠术,随后症状得以消除。病例报告之后是对贲门失弛缓症的流行病学、病因、临床表现、诊断和治疗的讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a38c/2578908/6401fc970d07/yjbm00021-0028-a.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验