伊朗结直肠癌的家族病史。
Family history of colorectal cancer in Iran.
作者信息
Mahdavinia Mahboobeh, Bishehsari Faraz, Ansari Reza, Norouzbeigi Nasim, Khaleghinejad Ahmad, Hormazdi Mahshid, Rakhshani Naser, Malekzadeh Reza
机构信息
Digestive Disease Research Centre, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
BMC Cancer. 2005 Sep 5;5:112. doi: 10.1186/1471-2407-5-112.
BACKGROUND
Previous reports show a high proportion of young CRC patients in Iran. In this study we aim to look for the clustering of colorectal cancer in families of a series of CRC patients from Iran.
METHODS
The family history of cancer is traced in 449 CRC patients of which 112 were 45 yrs or younger and 337 were older than 45 yrs at time of diagnosis. The patients were admitted in two hospitals in Tehran, during a 4-year period.
RESULTS
Clinical diagnosis of HNPCC was established in 21 (4.7%) probands. Family history of CRC was more frequently reported by early-onset than by late-onset patients (29.5% vs. 12.8%, p < 0.001). Distribution of tumor site differed significantly between those with and without family history of CRC. Right colon cancer was the most frequent site (23/45, 35.4%) observed in patients with positive family history of colorectal cancer.
CONCLUSION
The relatively high frequency of CRC clustering along with HNPCC in our patients should be further confirmed with larger sample size population-based and genetic studies to establish a cost effective molecular screening for the future.
背景
既往报告显示伊朗年轻结直肠癌患者比例较高。在本研究中，我们旨在探寻伊朗一系列结直肠癌患者家族中结直肠癌的聚集情况。
方法
追溯449例结直肠癌患者的癌症家族史，其中112例在诊断时年龄为45岁及以下，337例年龄大于45岁。这些患者在4年期间入住德黑兰的两家医院。
结果
21例（4.7%）先证者确诊为遗传性非息肉病性结直肠癌（HNPCC）。早发型患者比晚发型患者更常报告有结直肠癌家族史（29.5%对12.8%，p<0.001）。有和没有结直肠癌家族史的患者肿瘤部位分布有显著差异。右结肠癌是结直肠癌家族史阳性患者中最常见的部位（23/45，35.4%）。
结论
我们的患者中结直肠癌与HNPCC聚集的相对高频率应通过更大样本量的基于人群和基因的研究进一步证实，以便为未来建立具有成本效益的分子筛查方法。
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