Strik W K, Fallgatter A J, Brandeis D, Pascual-Marqui R D
Psychiatric Neurophysiology, Department of Psychiatry, University Hospital Wuerzburg, Germany.
Electroencephalogr Clin Neurophysiol. 1998 Jul;108(4):406-13. doi: 10.1016/s0168-5597(98)00021-5.
Spatial analysis of the evoked brain electrical fields during a cued continuous performance test (CPT) revealed an extremely robust anteriorization of the positivity of a P300 microstate in the NoGo compared to the Go condition (NoGo-anteriorization in a previous study). To allow a neuroanatomical interpretation the NoGo-anteriorization was investigated with a new three-dimensional source tomography method (LORETA) was applied.
The CPT contains subsets of stimuli requiring the execution (Go) or the inhibition (NoGo) of a cued motor response which can be considered as mutual control conditions for the event-related potential (ERP) study of inhibitory brain functions 21-channel ERPs were obtained from 10 healthy subjects during a cued CPT, and analyzed with LORETA.
Topographic analyses revealed significantly different scalp distributions between the Go and the NoGo conditions in both P100 and P300 microstates, indicating that already at an early stage different neural assemblies are activated. LORETA disclosed a significant hyperactivity located in the right frontal lobe during the NoGo condition in the P300 microstate.
The results indicate that right frontal sources are responsible for the NoGo-anteriorization of the scalp P300 which is consistent with animal and human lesion studies of inhibitory brain functions. Furthermore, it demonstrates that frontal activation is confined to a brief microstate and time-locked to phasic inhibitory motor control. This adds important functional and chronometric specificity to findings of frontal activation obtained with PET and Near-Infrared-Spectroscopy studies during the cued CPT, and suggests that these metabolic results are not due to general task demands.
在一项提示性连续作业测试（CPT）期间对诱发脑电场进行空间分析发现，与执行“Go”任务的情况相比，在“不执行（NoGo）”任务时，P300微状态的正性表现出极为显著的向前额方向集中（在之前的一项研究中发现的NoGo向前额方向集中现象）。为了进行神经解剖学解释，采用一种新的三维源断层扫描方法（低分辨率电磁断层成像，LORETA）对NoGo向前额方向集中现象进行了研究。
CPT包含一些刺激子集，这些刺激要求执行（Go）或抑制（NoGo）一个提示性运动反应，可将其视为用于抑制性脑功能事件相关电位（ERP）研究的相互对照条件。在提示性CPT期间，从10名健康受试者身上获取了21通道的ERP，并使用LORETA进行分析。
地形分析显示，在P100和P300微状态下，Go和NoGo条件之间的头皮分布存在显著差异，表明在早期阶段就激活了不同的神经组件。LORETA显示，在P300微状态的NoGo条件期间，右侧额叶存在显著的活动增强。
结果表明，右侧额叶源负责头皮P300的NoGo向前额方向集中，这与抑制性脑功能的动物和人类损伤研究结果一致。此外，研究表明额叶激活局限于一个短暂的微状态，并与阶段性抑制性运动控制在时间上锁定。这为在提示性CPT期间通过正电子发射断层扫描（PET）和近红外光谱研究获得的额叶激活结果增加了重要的功能和计时特异性，并表明这些代谢结果并非由一般任务需求所致。
