Mochizuki H, Scherer S W, Xi T, Nickle D C, Majer M, Huizenga J J, Tsui L C, Prochazka M
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institutes of Health, Phoenix, AZ 85016, USA.
Gene. 1998 Jun 15;213(1-2):149-57. doi: 10.1016/s0378-1119(98)00193-0.
We report the cloning and characterization of human PON2, a paraoxonase-related gene-2 that is physically linked with PON1 and PON3 on 7q2l.3. PON2 is ubiquitously expressed and we identified several mRNA forms produced by alternative splicing, or by the use of a second transcription start site. We also describe two polymorphisms in the coding sequences that, in the protein deduced from the longest open reading frame, predict an alanine-to-glycine substitution at residue 147 and a serine-to-cysteine substitution at residue 310.
