对氧磷酶 PON2 的相互作用组揭示了肿瘤生长调控的新途径。
Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation.
机构信息
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
All-Russia Research Institute of Agricultural Biotechnology, Moscow, Russia.
出版信息
Dokl Biochem Biophys. 2023 Feb;508(1):31-36. doi: 10.1134/S1607672922700089. Epub 2023 Jan 18.
The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2.
研究了由 PON2 基因编码的对氧磷酶 2 的相互作用组。使用酵母双杂交系统筛选 cDNA 文库，以寻找与人类 PON2 相互作用的新蛋白。对鉴定出的候选蛋白的分析，以及以前通过其他方法获得的相互作用蛋白的数据，表明 PON2 和 EGFR 之间存在大量间接相互作用，因此可能涉及 PON2 的突变型 EGFR 调节肿瘤生长。
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