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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Shi W, Wang H S, Pan Z, Wymore R S, Cohen I S, McKinnon D, Dixon J E

Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

J Physiol. 1998 Sep 15;511 ( Pt 3)(Pt 3):675-82. doi: 10.1111/j.1469-7793.1998.675bg.x.

Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

在大鼠中鉴定出了EAG钾通道基因家族的三个新成员，并通过cDNA克隆确定了其中一个基因（elk1）的完整编码序列。2. elk1基因在非洲爪蟾卵母细胞中表达时，编码一种激活缓慢且失活缓慢的钾通道。3. elk1基因在交感神经节中表达，也在坐骨神经中表达。4. 已发现七个已知EAG基因中的六个在大鼠交感神经节中表达，这表明这些通道在交感神经系统中具有重要的功能作用。

Shi W, Wang H S, Pan Z, Wymore R S, Cohen I S, McKinnon D, Dixon J E

Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.

J Physiol. 1998 Sep 15;511 ( Pt 3)(Pt 3):675-82. doi: 10.1111/j.1469-7793.1998.675bg.x.

Three new members of the EAG potassium channel gene family were identified in rat and the complete coding sequence of one of these genes (elk1) was determined by cDNA cloning. 2. The elk1 gene, when expressed in Xenopus oocytes, encodes a slowly activating and slowly deactivating potassium channel. 3. The elk1 gene is expressed in sympathetic ganglia and is also expressed in sciatic nerve. 4. Six of the seven known EAG genes were found to be expressed in rat sympathetic ganglia, suggesting an important functional role for these channels in the sympathetic nervous system.

在大鼠中鉴定出了EAG钾通道基因家族的三个新成员，并通过cDNA克隆确定了其中一个基因（elk1）的完整编码序列。2. elk1基因在非洲爪蟾卵母细胞中表达时，编码一种激活缓慢且失活缓慢的钾通道。3. elk1基因在交感神经节中表达，也在坐骨神经中表达。4. 已发现七个已知EAG基因中的六个在大鼠交感神经节中表达，这表明这些通道在交感神经系统中具有重要的功能作用。