Toyoda M, Kagoura M, Morohashi M
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
J Dermatol. 1998 Jul;25(7):434-7. doi: 10.1111/j.1346-8138.1998.tb02430.x.
We present a case of solitary basaloid follicular hamartoma of 8 years' duration on the nose of a 55-year-old Japanese man. Clinical examination revealed a solitary, asymptomatic, smooth-surfaced, black papule. Histologically, the lesion showed multifocal proliferation of basaloid cells forming islands, branching cords and anastomosing strands that were continuous with the basal layer of the epidermis. Individual hair follicles were replaced by these undifferentiated basaloid proliferating cells. Some abortive hair follicle-like structures composed of follicular bulbs and contiguous rudimentary dermal papillae were observed. This solitary papular type of basaloid follicular hamartoma is quite rare; our case is clearly distinguished from other neoplasms with hair follicle differentiation as well as from infundibulocystic basal cell carcinoma, which have been the most problematic differential diagnoses in the recent dermatopathologic literature.
我们报告一例发生于一名55岁日本男性鼻部、病程长达8年的孤立性基底样毛囊错构瘤。临床检查发现一个孤立的、无症状的、表面光滑的黑色丘疹。组织学上，病变显示基底样细胞多灶性增生，形成岛屿状、分支条索状和相互吻合的束状结构，与表皮基底层相连。单个毛囊被这些未分化的基底样增殖细胞取代。观察到一些由毛囊球和相邻的原始真皮乳头组成的发育不全的毛囊样结构。这种孤立丘疹型基底样毛囊错构瘤非常罕见；我们的病例与其他具有毛囊分化的肿瘤以及漏斗状囊性腺样基底细胞癌明显不同，而后者在最近的皮肤病理学文献中一直是最具诊断挑战性的鉴别诊断。
