Weinberg M A, Bral M
Department of Periodontics, New York University College of Dentistry, New York, 10010, USA.
Crit Rev Oral Biol Med. 1998;9(3):322-32. doi: 10.1177/10454411980090030501.
This article discusses the use of tetracyclines in the clinical management of periodontal infections. A review of the drugs pharmacology, pharmacokinetics, and potential adverse effects shows that they are relatively safe if used in appropriate dosages and under controlled conditions. Current data suggest that the routine use of tetracyclines in conjunction with the treatment of periodontitis is unnecessary. However, their distinctive characteristics can be utilized in different delivery systems as an adjunctive aid to conventional treatment of juvenile and refractory forms of periodontitis.
本文讨论了四环素在牙周感染临床治疗中的应用。对该药物的药理学、药代动力学及潜在不良反应的综述表明，若以适当剂量并在可控条件下使用，它们相对安全。目前的数据表明，常规将四环素与牙周炎治疗联合使用并无必要。然而，其独特特性可在不同给药系统中用作青少年牙周炎及难治性牙周炎传统治疗的辅助手段。
