Giannobile W V
Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor 48109-1078, USA.
Ann N Y Acad Sci. 1999 Jun 30;878:404-12. doi: 10.1111/j.1749-6632.1999.tb07698.x.
C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.
I型胶原的C-端肽及相关吡啶啉交联物是骨质疏松症和骨关节炎等溶骨性疾病中骨吸收的敏感标志物。我们研究了I型胶原的C-端肽吡啶啉交联物的释放情况，以此作为牙周疾病中骨破坏的指标。临床前动物模型和人体研究已经证明了影像学骨丢失与龈沟液C-端肽水平之间的关系。我们最近发现，C-端肽水平与牙周炎及骨内牙种植体周围的微生物病原体密切相关。人体研究表明，对与骨相关的胶原分解进行宿主调节，即抑制基质金属蛋白酶（MMP）可阻止活动期牙周病患者的组织破坏和C-端肽的释放。
