C端肽吡啶交联。牙周组织破坏的敏感指标。
C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction.
作者信息
Giannobile W V
机构信息
Department of Periodontics/Prevention/Geriatrics, University of Michigan, Ann Arbor 48109-1078, USA.
出版信息
Ann N Y Acad Sci. 1999 Jun 30;878:404-12. doi: 10.1111/j.1749-6632.1999.tb07698.x.
Abstract
C-telopeptides and related pyridinoline cross-links of bone Type I collagen are sensitive markers of bone resorption in osteolytic diseases such as osteoporosis and osteoarthritis. We have studied the release of C-telopeptide pyridinoline crosslinks of Type I collagen as measures of bone destruction in periodontal disease. Studies in preclinical animal models and humans have demonstrated the relationship between radiographic bone loss and crevicular fluid C-telopeptide levels. We have recently found that C-telopeptide levels correlate strongly with microbial pathogens associated with periodontitis and around endosseous dental implants. Host-modulation of bone-related collagen breakdown has been shown by studies in humans demonstrating that MMP inhibition blocks tissue destruction and release of C-telopeptides in patients with active periodontal disease.
摘要
I型胶原的C-端肽及相关吡啶啉交联物是骨质疏松症和骨关节炎等溶骨性疾病中骨吸收的敏感标志物。我们研究了I型胶原的C-端肽吡啶啉交联物的释放情况，以此作为牙周疾病中骨破坏的指标。临床前动物模型和人体研究已经证明了影像学骨丢失与龈沟液C-端肽水平之间的关系。我们最近发现，C-端肽水平与牙周炎及骨内牙种植体周围的微生物病原体密切相关。人体研究表明，对与骨相关的胶原分解进行宿主调节，即抑制基质金属蛋白酶（MMP）可阻止活动期牙周病患者的组织破坏和C-端肽的释放。
相似文献
1
C-telopeptide pyridinoline cross-links. Sensitive indicators of periodontal tissue destruction.C端肽吡啶交联。牙周组织破坏的敏感指标。
Ann N Y Acad Sci. 1999 Jun 30;878:404-12. doi: 10.1111/j.1749-6632.1999.tb07698.x.
2
C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants.C-末端肽吡啶啉交联物（ICTP）与骨内口腔种植体相关的牙周病原体
Clin Oral Implants Res. 1998 Dec;9(6):365-73. doi: 10.1034/j.1600-0501.1996.090602.x.
3
Effect of non-surgical periodontal therapy on C-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels.非手术牙周治疗对C-末端肽吡啶交联物（ICTP）和白细胞介素-1水平的影响。
J Periodontol. 2001 Aug;72(8):1045-51. doi: 10.1902/jop.2001.72.8.1045.
4
Crevicular fluid osteocalcin and pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs.龈沟液骨钙素和I型胶原吡啶啉交联羧基末端肽（ICTP）作为牙周炎中快速骨转换的标志物。在比格犬中的一项初步研究。
J Clin Periodontol. 1995 Dec;22(12):903-10. doi: 10.1111/j.1600-051x.1995.tb01793.x.
5
[Bone resorption markers].[骨吸收标志物]
Rinsho Byori. 1996 May;44(5):415-22.
6
Effect of locally delivered minocycline microspheres on markers of bone resorption.局部递送米诺环素微球对骨吸收标志物的影响。
J Periodontol. 2002 Aug;73(8):835-42. doi: 10.1902/jop.2002.73.8.835.
7
C-telopeptide pyridinoline crosslinks of type I collagen, soluble RANKL, and osteoprotegerin levels in crevicular fluid of dental implants with peri-implantitis: a case-control study.种植体周围炎患者种植体周围液中Ⅰ型胶原 C-末端肽吡啶交联物、可溶性核因子κB 受体激活物配体和骨保护素水平的病例对照研究。
Int J Oral Maxillofac Implants. 2011 Mar-Apr;26(2):282-9.
8
Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis.C-末端肽吡啶啉交联（ICTP）与牙周炎中假定的牙周病原体之间的关系。
J Clin Periodontol. 1998 Nov;25(11 Pt 1):865-71. doi: 10.1111/j.1600-051x.1998.tb02383.x.
9
Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial.炎症状态对患有种植体周围炎的口腔种植体周围I型胶原C-末端吡啶啉交联和骨钙素水平的可能影响：一项对照临床试验。
J Oral Rehabil. 2008 Dec;35(12):934-9. doi: 10.1111/j.1365-2842.2008.01879.x.
10
Advances in periodontal diagnosis. 10. Potential markers of bone resorption.
Br Dent J. 1998 May 23;184(10):489-92. doi: 10.1038/sj.bdj.4809670.
引用本文的文献
1
Estimation of Levels of Salivary Pyridinoline Cross-Linked Carboxyterminal Telopeptide of Type I Collagen (ICTP) in Periodontally Healthy and Diseased Patients at Various Time Intervals Before and After Periodontal Therapy.牙周治疗前后不同时间间隔对牙周健康和患病患者唾液中 I 型胶原吡啶啉交联羧基末端肽（ICTP）水平的评估。
Cureus. 2024 Aug 5;16(8):e66236. doi: 10.7759/cureus.66236. eCollection 2024 Aug.
2
Using 8-Hydroxy-2'-Deoxiguanosine (8-OHdG) as a Reliable Biomarker for Assessing Periodontal Disease Associated with Diabetes.将 8-羟基-2'-脱氧鸟苷（8-OHdG）用作评估与糖尿病相关的牙周病的可靠生物标志物。
Int J Mol Sci. 2024 Jan 24;25(3):1425. doi: 10.3390/ijms25031425.
3
Metabolic Conditions and Peri-Implantitis.代谢状况与种植体周围炎
Antibiotics (Basel). 2022 Dec 29;12(1):65. doi: 10.3390/antibiotics12010065.
4
A Roadmap towards Precision Periodontics.精准牙周病学路线图
Medicina (Kaunas). 2021 Mar 3;57(3):233. doi: 10.3390/medicina57030233.
5
Biosensor and Lab-on-a-chip Biomarker-identifying Technologies for Oral and Periodontal Diseases.用于口腔和牙周疾病的生物传感器及芯片实验室生物标志物识别技术
Front Pharmacol. 2020 Nov 9;11:588480. doi: 10.3389/fphar.2020.588480. eCollection 2020.
6
Calprotectin and cross-linked N-telopeptides of type I collagen levels in crevicular fluid from implant sites with peri-implant diseases: a pilot study.种植体周围疾病种植位点龈沟液中钙卫蛋白及I型胶原交联N-末端肽水平：一项初步研究
Int J Implant Dent. 2018 Sep 13;4(1):26. doi: 10.1186/s40729-018-0138-2.
7
MicroRNAs and immunity in periodontal health and disease.微小 RNA 与牙周健康和疾病中的免疫。
Int J Oral Sci. 2018 Aug 6;10(3):24. doi: 10.1038/s41368-018-0025-y.
8
Saliva diagnostics - Current views and directions.唾液诊断——当前观点与方向
Exp Biol Med (Maywood). 2017 Mar;242(5):459-472. doi: 10.1177/1535370216681550. Epub 2016 Dec 8.
9
Gingival crevicular fluid as a source of biomarkers for periodontitis.龈沟液作为牙周炎生物标志物的来源
Periodontol 2000. 2016 Feb;70(1):53-64. doi: 10.1111/prd.12107.
10
Periodontal proteomics: wonders never cease!牙周蛋白质组学：奇迹永无止境！
Int J Proteomics. 2013;2013:850235. doi: 10.1155/2013/850235. Epub 2013 Dec 31.
本文引用的文献
1
C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants.C-末端肽吡啶啉交联物（ICTP）与骨内口腔种植体相关的牙周病原体
Clin Oral Implants Res. 1998 Dec;9(6):365-73. doi: 10.1034/j.1600-0501.1996.090602.x.
2
Longitudinal studies of implant systems.植入系统的纵向研究。
Periodontol 2000. 1998 Jun;17:125-31. doi: 10.1111/j.1600-0757.1998.tb00130.x.
3
Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis.C-末端肽吡啶啉交联（ICTP）与牙周炎中假定的牙周病原体之间的关系。
J Clin Periodontol. 1998 Nov;25(11 Pt 1):865-71. doi: 10.1111/j.1600-051x.1998.tb02383.x.
4
Tetracycline and its analogues: a therapeutic paradigm in periodontal diseases.四环素及其类似物：牙周疾病的一种治疗模式
Crit Rev Oral Biol Med. 1998;9(3):322-32. doi: 10.1177/10454411980090030501.
5
Crevicular fluid biomarkers of oral bone loss.口腔骨质流失的龈沟液生物标志物。
Curr Opin Periodontol. 1997;4:11-20.
6
Serum concentration of the pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a useful indicator of decline and recovery of bone mineral density in lumbar spine: analysis in Japanese postmenopausal women with or without hormone replacement.血清I型胶原吡啶啉交联羧基末端肽（ICTP）浓度是腰椎骨密度下降和恢复的有用指标：对日本绝经后接受或未接受激素替代治疗女性的分析
Endocr J. 1998 Feb;45(1):45-51. doi: 10.1507/endocrj.45.45.
7
Microbial complexes in subgingival plaque.龈下菌斑中的微生物复合体
J Clin Periodontol. 1998 Feb;25(2):134-44. doi: 10.1111/j.1600-051x.1998.tb02419.x.
8
A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis.一种基质金属蛋白酶抑制剂可减少成人牙周炎期间龈沟液中的骨型胶原降解片段和特定胶原酶。
Inflamm Res. 1997 Aug;46(8):310-9. doi: 10.1007/s000110050193.
9
Evaluation of components of gingival crevicular fluid as diagnostic tests.评估龈沟液成分作为诊断测试的情况。
Ann Periodontol. 1997 Mar;2(1):123-37. doi: 10.1902/annals.1997.2.1.123.
10
The nature of periodontal diseases.
Ann Periodontol. 1997 Mar;2(1):3-10. doi: 10.1902/annals.1997.2.1.3.
Zotero 插件