Rajagopalan M, Kurian G, John J
Ballarat Health Services, Victoria, Australia.
J Gastroenterol Hepatol. 1998 Jul;13(7):738-41. doi: 10.1111/j.1440-1746.1998.tb00723.x.
Anti-depressants have been reported to be useful in the management of the Irritable Bowel syndrome. We studied the efficacy of amitriptyline for 12 weeks in a randomized double-blind placebo-controlled trial. Forty patients who met predefined criteria entered the trial. They received 25 mg amitriptyline for the first week, 50 mg for the second week and 75 mg nightly thereafter until the end of the 12th week. The drug and placebo groups were comparable in all major pretreatment variables. Amitriptyline was found to be significantly more effective than placebo in producing global improvement, increasing feelings of well-being, reducing abdominal pain and increasing satisfaction with bowel movements. Younger age and increasing extroversion predicted a better response to amitriptyline. Severity of depressive and anxiety symptoms and other personality variables did not influence outcome.
据报道，抗抑郁药对肠易激综合征的治疗有效。我们在一项随机双盲安慰剂对照试验中研究了阿米替林12周的疗效。40名符合预定义标准的患者进入试验。他们在第一周服用25毫克阿米替林，第二周服用50毫克，此后每晚服用75毫克，直至第12周结束。药物组和安慰剂组在所有主要的预处理变量方面具有可比性。结果发现，在实现整体改善、增强幸福感、减轻腹痛以及提高对排便的满意度方面，阿米替林比安慰剂显著更有效。年龄较小和性格更外向预示着对阿米替林的反应更好。抑郁和焦虑症状的严重程度以及其他人格变量并未影响治疗结果。
