Hug B, Kaeser Y A, Haefeli W E, Battegay M
Medizinische Universitätspoliklinik, Departement Innere Medizin, Kantonsspital Basel.
Schweiz Med Wochenschr. 1998 Jul 21;128(29-30):1138-44.
Therapy of HIV infection is changing rapidly as new drugs are introduced. Many patients with HIV infection require anticonvulsants for therapy or prophylaxis of seizures. Antiretroviral drugs, above all protease inhibitors, and anticonvulsants may cause interactions since they are metabolised through common hepatic pathways and may substantially modulate the activity of numerous cytochrome P450 isoenzymes. We describe known interactions between anticonvulsants and antiretroviral drugs and advise on possible combinations.
随着新药的推出，HIV感染的治疗正在迅速变化。许多HIV感染患者需要使用抗惊厥药来治疗或预防癫痫发作。抗逆转录病毒药物，尤其是蛋白酶抑制剂，与抗惊厥药可能会产生相互作用，因为它们通过共同的肝脏途径代谢，并且可能会显著调节多种细胞色素P450同工酶的活性。我们描述了抗惊厥药与抗逆转录病毒药物之间已知的相互作用，并就可能的联合用药提出建议。
