Bluthenthal R N, Kral A H, Erringer E A, Edlin B R
Urban Health Study, Institute for Health Policy Studies, School of Medicine, University of California, San Francisco 94143-1304, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Aug 15;18(5):505-11. doi: 10.1097/00042560-199808150-00013.
To determine factors associated with syringe and injection supply sharing among injection drug users (IDUs) in a community with an illegal underground syringe exchange program (SEP).
From 1992 to 1995, semiannual cross-sectional samples of IDUs were recruited in Oakland, California. To account for multiple observations from the same individual, we used general estimating equations with logit transformations to determine factors associated with sharing syringes and other injection supplies.
1304 IDUs were interviewed; 684 (53%) returned for more than one interview. 2830 interviews were available for analysis. SEP use increased and syringe and supply sharing declined from 1992 to 1995 among study participants. In multivariate analysis, SEP users were less likely to share syringes than non-SEP users (adjusted odds ratio [AOR] = 0.57; 95% confidence interval [CI] = 0.46-0.72). SEP use was not significantly associated with the sharing of injection supplies (AOR = 0.85; 95% CI = 0.68-1.07). Syringe sharing and injection supply sharing were significantly less likely to occur among African American and HIV-positive IDUs.
These data suggest that illegal SEPs can be effective HIV prevention programs. Lower rates of syringe-based risk behaviors among African American and HIV-positive IDUs are encouraging.
确定在存在非法地下注射器交换项目(SEP)的社区中,注射吸毒者(IDU)之间注射器及注射用品共享的相关因素。
1992年至1995年期间,在加利福尼亚州奥克兰招募了IDU的半年期横断面样本。为了考虑同一人的多次观察结果,我们使用了带有logit变换的广义估计方程来确定与注射器及其他注射用品共享相关的因素。
对1304名IDU进行了访谈;684人(53%)返回接受了不止一次访谈。共有2830次访谈可供分析。在研究参与者中,1992年至1995年期间SEP的使用增加,注射器及用品共享减少。在多变量分析中,SEP使用者比非SEP使用者共享注射器的可能性更小(调整后的优势比[AOR]=0.57;95%置信区间[CI]=0.46 - 0.72)。SEP的使用与注射用品的共享无显著关联(AOR = 0.85;95% CI = 0.68 - 1.07)。非裔美国人和HIV阳性的IDU中,注射器共享和注射用品共享的发生率显著更低。
这些数据表明非法的SEP可以成为有效的艾滋病预防项目。非裔美国人和HIV阳性的IDU中基于注射器的风险行为发生率较低,令人鼓舞。