Wallin A
Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Göteborg University, Sahlgrenska University Hospital, Mölndal, Sweden. anders.wallin@msse
Dement Geriatr Cogn Disord. 1998 Jul;9 Suppl 1:30-5. doi: 10.1159/000051187.
As there is some overlap between Alzheimer's disease (AD) and vascular dementia (VaD), it can be assumed that some particular features that they have in common are responsible for this overlap. One of the candidates is white matter changes whose presence in variants of the two entities is described in this paper. A common, although much debated, division of AD is into two types, type I usually with early and type II usually with late onset. As to VaD, the division can be based on neuropathological changes and vascular disease mechanisms. In one subtype, 'subcortical white matter dementia', white matter lesions are conspicuous features. The overlap between this subtype and AD type I is small, but the overlap is considerable between the same subcortical subtype and AD type II. In the latter, white matter changes and Alzheimer encephalopathy may interact to produce dementia.
由于阿尔茨海默病（AD）和血管性痴呆（VaD）之间存在一些重叠，可以推测它们共有的一些特定特征是造成这种重叠的原因。其中一个候选因素是白质变化，本文描述了这两种疾病变体中白质变化的存在情况。AD常见的一种分类（尽管存在很多争议）是分为两种类型，I型通常起病较早，II型通常起病较晚。至于VaD，其分类可以基于神经病理学变化和血管疾病机制。在一种亚型“皮质下白质痴呆”中，白质病变是显著特征。该亚型与AD I型之间的重叠较小，但同一皮质下亚型与AD II型之间的重叠相当大。在后者中，白质变化和阿尔茨海默脑病可能相互作用导致痴呆。
