Gold G, Giannakopoulos P, Bouras C
Department of Geriatric, University of Geneva School of Medicine, Geneva, Switzerland.
Eur Neurol. 1998 Oct;40(3):121-9. doi: 10.1159/000007968.
Alzheimer's disease (AD) and vascular dementia (VaD) are the two most common causes of dementia, and much effort has been devoted to their differential diagnosis. However, current epidemiological, clinical and neuropathological evidence points to a substantial overlap between AD and VaD and suggests that vascular pathology, the traditional cornerstone of the differential diagnosis between the two entities, may not represent as clear a line of demarcation as originally believed. It may be time to reevaluate the dichotomy between AD and VaD.
阿尔茨海默病（AD）和血管性痴呆（VaD）是痴呆症最常见的两种病因，人们在二者的鉴别诊断方面投入了大量精力。然而，目前的流行病学、临床和神经病理学证据表明，AD和VaD之间存在大量重叠，这表明血管病理学这一传统上区分这两种疾病的基石，可能并不像最初认为的那样是一条清晰的分界线。或许是时候重新评估AD和VaD之间的二分法了。
