Zembower T R, Noskin G A, Postelnick M J, Nguyen C, Peterson L R
Department of Medicine, Northwestern Memorial Hospital and Northwestern University Medical School, Chicago, IL 60611, USA.
Int J Antimicrob Agents. 1998 May;10(2):95-105. doi: 10.1016/s0924-8579(98)00033-8.
As the problem of global antibiotic resistance continues to worsen, aminoglycosides have assumed increasing importance in clinical practice. Their broad antimicrobial spectrum, rapid bactericidal action, and ability to act synergistically with other drugs have made them especially useful in the treatment of serious nosocomial infections. However, as with other drugs, their overuse and misuse leads to the development of resistance in important microbial pathogens. The appropriate use of the aminoglycosides is essential to assure their continued efficacy. Therefore, physicians must familiarize themselves with both the clinical indications and the limitations of these drugs if they are to remain efficacious in the years to come.
随着全球抗生素耐药性问题持续恶化，氨基糖苷类药物在临床实践中的重要性日益凸显。它们广泛的抗菌谱、快速的杀菌作用以及与其他药物协同作用的能力，使其在治疗严重医院感染方面特别有用。然而，与其他药物一样，它们的过度使用和滥用会导致重要微生物病原体产生耐药性。合理使用氨基糖苷类药物对于确保其持续有效性至关重要。因此，如果要在未来几年保持疗效，医生必须熟悉这些药物的临床适应症和局限性。
