Knudsen L L, Nielsen-Kudsk F
Department of Ophthalmology, Odense University Hospital, Denmark.
Acta Ophthalmol Scand. 1998 Aug;76(4):396-400. doi: 10.1034/j.1600-0420.1998.760402.x.
Describe and compare drug exchange between various parts of the eye.
Fluorophotometric measurements of the anterior chamber, vitreous and plasma fluorescein concentrations were performed and subjected to a kinetic two-compartment analysis.
The overall barrier properties as revealed by a permeability-index were found to be 12.2% and 3.5% for the anterior chamber and the vitreous, respectively. The apparent rate constant of permeation into the anterior chamber was found to be significantly higher than into the vitreous and the apparent peripheral body compartment. The terminal rate constant of fluorescein disposition from the anterior chamber was in agreement with the terminal disposition rate constant for plasma fluorescein, whereas elimination from the vitreous was significantly slower.
Compartment analysis of ocular fluorescein kinetics is suitable for the study of anterior and posterior barrier properties in the eye. In this study fluorescein elimination from the anterior chamber was restricted by terminal plasma fluorescein decay rather than by ocular tissue.
描述并比较眼部各部位之间的药物交换情况。
对前房、玻璃体和血浆中的荧光素浓度进行荧光光度测量，并进行动力学双室分析。
通过渗透指数揭示的总体屏障特性，前房和玻璃体分别为12.2%和3.5%。发现荧光素进入前房的表观渗透速率常数显著高于进入玻璃体和外周体腔的速率常数。荧光素从前房清除的终末速率常数与血浆荧光素的终末清除速率常数一致，而从玻璃体清除则明显较慢。
眼部荧光素动力学的房室分析适用于研究眼部前后屏障特性。在本研究中，荧光素从前房的清除受血浆荧光素终末衰减的限制，而非眼部组织的限制。
