正常受试者前房荧光素动力学与玻璃体动力学的比较。

Anterior chamber fluorescein kinetics compared with vitreous kinetics in normal subjects.

作者信息

Knudsen L L, Olsen T, Nielsen-Kudsk F

机构信息

Department of Ophthalmology, Odense University Hospital, Denmark.

出版信息

Acta Ophthalmol Scand. 1998 Oct;76(5):561-7. doi: 10.1034/j.1600-0420.1998.760510.x.

DOI:10.1034/j.1600-0420.1998.760510.x

PMID:9826040

Abstract

PURPOSE

Describe and compare barrier properties in various parts of the eye.

METHODS

Fluorophotometric measurements of the anterior chamber, vitreous and plasma fluorescein concentrations were performed and subjected to a kinetic two-compartment analysis.

RESULTS

The overall barrier properties as revealed by a permeability-index was found to be 12.2% (anterior chamber) and 3.5% (vitreous). The apparent rate constant of permeation into the anterior chamber (Kin=1,59 h(-1)) was found to be significantly higher than into the vitreous (Kin=0,66 h(-1)) and into the apparent peripheral body compartment (Kin=0,23 h(-1)). The terminal rate constant of fluorescein disposition from the anterior chamber (Kout=0,21 h(-1)) was in agreement with the terminal disposition rate constant for plasma fluorescein (P=0,23 h(-1)), whereas elimination from the vitreous (Kout=0,072 h(-1)) was significantly slower.

CONCLUSION

Compartment analysis of ocular fluorescein kinetics is suitable for the study of anterior and posterior barrier properties in the eye. In this study fluorescein elimination from the anterior chamber was restricted by terminal plasma fluorescein decay rather than by ocular tissue.

摘要

目的

描述并比较眼部各部位的屏障特性。

方法

对前房、玻璃体和血浆中的荧光素浓度进行荧光光度测量，并进行动力学双室分析。

结果

通过渗透指数揭示的总体屏障特性在前房为12.2%，在玻璃体为3.5%。发现荧光素进入前房的表观渗透速率常数（Kin = 1.59 h⁻¹）显著高于进入玻璃体（Kin = 0.66 h⁻¹）和进入表观外周体室（Kin = 0.23 h⁻¹）的速率常数。荧光素从前房清除的终末速率常数（Kout = 0.21 h⁻¹）与血浆荧光素的终末清除速率常数（P = 0.23 h⁻¹）一致，而从玻璃体清除（Kout = 0.072 h⁻¹）则明显较慢。