van Boxtel C J, Wilson J T, Lindgren S, Sjöqvist F
Eur J Clin Pharmacol. 1976 Feb 6;9(4):327-32. doi: 10.1007/BF00561668.
A previously described GLC method has been modified and applied to measurement of antipyrine levels in plasma, blood and saliva of man following administration of a single oral dose (10 mg/kg). Tery time studied. The half-life of antipyrine determined in blood, plasma or saliva in any given individual was similar. The intersubject variation in half-life was about two-fold (n = 5). Antipyrine levels in saliva were not affected by the rate of saliva flow when collections were made continuously for 20 minutes. This study has demonstrated that kinetic data about antipyrine comparable to that from plasma may also be obtained from readily accessible tissue fluids, such as saliva and capillary blood.
一种先前描述的气相色谱法已被改进，并应用于单次口服剂量（10毫克/千克）后人体血浆、血液和唾液中安替比林水平的测定。在研究的每个时间点，在任何给定个体的血液、血浆或唾液中测定的安替比林半衰期相似。个体间半衰期的差异约为两倍（n = 5）。当连续收集20分钟时，唾液流速不影响唾液中安替比林水平。本研究表明，也可从易于获取的组织液（如唾液和毛细血管血）中获得与血浆相当的安替比林动力学数据。
