致命阿片类药物过量。硅烷化后通过气相色谱-质谱联用仪对血样中各种代谢物进行毒理学鉴定。

Fatal opiates overdose. Toxicological identification of various metabolites in a blood sample by GC-MS after silylation.

作者信息

Balíková M, Maresová V

机构信息

Institute for Toxicology and Forensic Chemistry, 1st Medical Faculty and Hospital, Charles University, Prague, Czech Republic.

出版信息

Forensic Sci Int. 1998 Jun 22;94(3):201-9. doi: 10.1016/s0379-0738(98)00077-2.

DOI:10.1016/s0379-0738(98)00077-2

PMID:9717273

Abstract

A fatal opiates overdose, where ethylmorphine, hydrocodone, dihydrocodeine and codeine were consumed concomitantly, is reported. This case report may contribute to data on fatal blood concentrations of drugs with rare incidence. The relative retention times in capillary gas chromatography and full mass spectra of various opiates in their silylated forms, detected together in one sample, may serve as a helpful analytical reference for clinical and forensic toxicologists.

摘要

据报道，有一例致命的阿片类药物过量案例，患者同时服用了乙基吗啡、氢可酮、二氢可待因和可待因。该病例报告可能有助于补充罕见药物致死血药浓度的数据。在一个样本中同时检测到的各种阿片类药物硅烷化形式在毛细管气相色谱中的相对保留时间和全质谱，可为临床和法医毒理学家提供有用的分析参考。