Schuurman A G, Goldbohm R A, Dorant E, van den Brandt P A
Department of Epidemiology, Maastricht University, The Netherlands.
Cancer Epidemiol Biomarkers Prev. 1998 Aug;7(8):673-80.
The association between 21 vegetables and eight fruits and prostate cancer risk was assessed in the Netherlands Cohort Study among 58,279 men of ages 55-69 years at baseline in 1986. After 6.3 years of follow-up, 610 cases with complete vegetable data and 642 cases with complete fruit data were available for analysis. In multivariate case-cohort analyses, the following rate ratios (RRs) and 95% confidence intervals (CIs) for vegetable consumption were found (comparing highest versus lowest quintile): total vegetables (RR, 0.80; CI, 0.57-1.12); prepared vegetables (RR, 0.85; CI, 0.61-1.19); and raw vegetables (RR, 0.96; CI, 0.69-1.34). For vegetables categorized in botanical groups, no associations were found except for consumption of pulses (RR, 0.71; CI, 0.51-0.98; P for trend, 0.01). The RRs for total fruit and citrus fruit were 1.31 (CI, 0.96-1.79) and 1.27 (CI, 0.93-1.73), respectively; the corresponding Ps for trend were 0.02 and 0.01, respectively. In a continuous model, no association for total fruit was observed. Individual vegetables and fruits were evaluated as continuous variables (g/day). Nonsignificant inverse associations (RRs per increment of 25 g/day) were found for consumption of kale (RR, 0.74), raw endive (RR, 0.72), mandarins (RR, 0.75), and raisins or other dried fruit (RR, 0.49). Observed positive associations were significant for consumption of leek (RR, 1.38) and oranges (RR, 1.07) and nonsignificant for sweet peppers (RR, 1.60) and mushrooms (RR, 1.49). Results in subgroups of cases were more or less consistent with the overall results. From our study, we cannot conclude that vegetable consumption is important in prostate cancer etiology, but for certain vegetables or fruits, an association cannot be excluded.
在荷兰队列研究中，对1986年基线时年龄在55至69岁的58279名男性进行了21种蔬菜和8种水果与前列腺癌风险之间关联的评估。经过6.3年的随访，有610例具备完整蔬菜数据的病例和642例具备完整水果数据的病例可供分析。在多变量病例队列分析中，发现蔬菜摄入量的以下率比（RRs）和95%置信区间（CIs）（比较最高五分位数与最低五分位数）：总蔬菜（RR，0.80；CI，0.57 - 1.12）；加工蔬菜（RR，0.85；CI，0.61 - 1.19）；以及生蔬菜（RR，0.96；CI，0.69 - 1.34）。对于按植物学类别分类的蔬菜，除了食用豆类外未发现关联（RR，0.71；CI，0.51 - 0.98；趋势P值，0.01）。总水果和柑橘类水果的RR分别为1.31（CI，0.96 - 1.79）和1.27（CI，0.93 - 1.73）；相应的趋势P值分别为0.02和0.01。在连续模型中，未观察到总水果的关联。将个体蔬菜和水果作为连续变量（克/天）进行评估。食用羽衣甘蓝（RR，0.74）、生苦苣（RR，0.72）、柑橘（RR，0.75）以及葡萄干或其他果干（RR，0.49）时发现了无统计学意义的负相关。观察到的正相关在食用韭菜（RR，1.38）和橙子（RR，1.07）时具有统计学意义，而在食用甜椒（RR，1.60）和蘑菇（RR，1.49）时无统计学意义。病例亚组的结果与总体结果或多或少一致。从我们的研究中，我们不能得出蔬菜消费在前列腺癌病因学中很重要的结论，但对于某些蔬菜或水果，不能排除存在关联。
