Whittaker J C, Lewis C M
Department of Applied Statistics, University of Reading, Reading, United Kingdom.
Am J Hum Genet. 1998 Sep;63(3):889-97. doi: 10.1086/302008.
We considered the problem of testing a marker for linkage with a disease, using tests based on the transmission-disequilibrium test (TDT). The power of such tests was investigated for a number of possible family types, for which the families were classified by the disease status of family individuals. We show that parental disease status greatly affects the power, with families containing a single affected parent often preferred over families in which neither parent is affected. Families with a pair of affected sibs are of great value for all situations considered, but extension of the TDT to allow inclusion of information from unaffected sibs rarely increases power, if the parents have been genotyped.
我们考虑了使用基于传递不平衡检验（TDT）的测试来检测与疾病连锁的标记物的问题。针对多种可能的家庭类型研究了此类测试的效能，这些家庭根据家庭成员的疾病状态进行分类。我们表明，父母的疾病状态对效能有很大影响，通常包含一位患病父母的家庭比父母均未患病的家庭更受青睐。对于所有考虑的情况，有一对患病同胞的家庭具有很大价值，但如果对父母进行了基因分型，将TDT扩展以纳入未患病同胞的信息很少能提高效能。
