Lanas A, Bajador E, Serrano P, Arroyo M, Fuentes J, Santolaria S
Service of Gastroenterology, University Hospital, Zaragoza, Spain.
J Int Med Res. 1998 Jun-Jul;26(3):120-8. doi: 10.1177/030006059802600302.
Experimental studies suggest that nitric-oxide releasing drugs reduce gastroduodenal damage induced by non-steroidal anti-inflammatory drugs, but it is not known whether these agents have this effect in humans. The aim of the present study was to evaluate the risk of upper gastrointestinal bleeding in patients who receive aspirin and nitrates for vascular occlusive diseases. This was a retrospective case-control study of 736 consecutive patients admitted with upper gastrointestinal bleeding, compared with 1472 age- and sex-matched hospital controls. Chronic low-dose aspirin regimens had been used by 12.6% of cases and 5.7% of controls, nitrates by 4.8% and 5.8%, and combined nitrates and low-dose aspirin by 2.7% and 1.9%, respectively. Logistic regression analysis identified low-dose aspirin use as an independent risk factor for gastrointestinal bleeding, whereas nitrate use was found to be a protective factor. The combination of both nitrate and low-dose aspirin was not associated with an increased risk of bleeding.
实验研究表明，释放一氧化氮的药物可减轻非甾体抗炎药所致的胃十二指肠损伤，但这些药物在人体中是否具有此作用尚不清楚。本研究的目的是评估接受阿司匹林和硝酸盐治疗血管闭塞性疾病的患者发生上消化道出血的风险。这是一项回顾性病例对照研究，纳入了736例连续因上消化道出血入院的患者，并与1472例年龄和性别匹配的医院对照进行比较。病例组和对照组分别有12.6%和5.7%的患者长期使用低剂量阿司匹林方案，4.8%和5.8%的患者使用硝酸盐，2.7%和1.9%的患者联合使用硝酸盐和低剂量阿司匹林。逻辑回归分析确定使用低剂量阿司匹林是胃肠道出血的独立危险因素，而使用硝酸盐则是保护因素。硝酸盐和低剂量阿司匹林联合使用与出血风险增加无关。
