Wahlbeck K, Ahokas A, Miettinen K, Nikkilä H, Rimón R
Dept. of Psychiatry, University of Helsinki, Finland.
Schizophr Bull. 1998;24(3):391-7. doi: 10.1093/oxfordjournals.schbul.a033334.
The aim of this study was to replicate our earlier finding of elevated angiotensin-converting enzyme (ACE) in cerebrospinal fluid (CSF) in schizophrenia and to elucidate the role of neuroleptic treatment in this phenomenon. Drug-free and medicated patients with acute schizophrenic psychoses, as well as healthy controls were recruited. Levels of ACE were measured in CSF and serum from 7 drug-free patients, 36 neuroleptic-treated patients, and 19 healthy control subjects. Although ACE levels in CSF did not differ between patients and controls, the drug-free patients showed significantly lower levels than the neuroleptic-treated patients. Serum ACE did not differ between groups. The elevation of CSF ACE may be more prominent in patients with deficit symptoms than in those with mainly psychotic symptoms. The possible enhancement of CSF ACE production or solubility by neuroleptic treatment is discussed. Elevated ACE levels in CSF may, together with other possible factors, cause polydipsia, stimulate secretion of arginine vasopressin, and even affect neuron growth and differentiation in schizophrenic psychoses.
本研究的目的是重复我们之前的发现，即精神分裂症患者脑脊液（CSF）中的血管紧张素转换酶（ACE）升高，并阐明抗精神病药物治疗在这一现象中的作用。招募了患有急性精神分裂症精神病的未服药和服药患者以及健康对照者。测量了7名未服药患者、36名接受抗精神病药物治疗的患者和19名健康对照者的脑脊液和血清中的ACE水平。虽然患者和对照者脑脊液中的ACE水平没有差异，但未服药患者的水平明显低于接受抗精神病药物治疗的患者。各组血清ACE无差异。与主要有精神病性症状的患者相比，有缺陷症状的患者脑脊液ACE升高可能更明显。讨论了抗精神病药物治疗可能增强脑脊液ACE产生或溶解性的情况。脑脊液中ACE水平升高可能与其他可能因素一起，导致烦渴，刺激精氨酸加压素分泌，甚至影响精神分裂症精神病中的神经元生长和分化。
