Miekeley N, Dias Carneiro M T, da Silveira C L
Pontifical Catholic University (PUC-Rio), Rio de Janeiro, Brazil.
Sci Total Environ. 1998 Jul 11;218(1):9-17. doi: 10.1016/s0048-9697(98)00185-5.
Inductively coupled plasma mass spectrometry (ICP-MS) was used for the determination of major and trace element concentrations in scalp hair samples from a population group (N = 1091) of Rio de Janeiro city. From these results, preliminary 'normal' or reference intervals were calculated which are for several trace elements (e.g. B, V, Co, Ge, Mo, Au, As, Se, Sb, Th), but also for some minor elements (e.g. Ca, Mg) in disaccord with data published by five clinical laboratories which used inductively coupled plasma atomic emission spectrometry (ICP-AES). The limitations of ICP-AES in routine hair analysis is shown by comparison of detection limits for both methods and by results from two laboratory intercomparison exercises. It is evident from these data that published reference intervals have to be used with extreme caution and that their urgent revision, based on reliable data produced by the ICP-MS technique, is of extreme importance.
采用电感耦合等离子体质谱法（ICP-MS）测定了里约热内卢市一组人群（N = 1091）头皮毛发样本中的主要和微量元素浓度。根据这些结果，计算出了初步的“正常”或参考区间，这些区间适用于多种微量元素（如硼、钒、钴、锗、钼、金、砷、硒、锑、钍），也适用于一些常量元素（如钙、镁），但与五个使用电感耦合等离子体原子发射光谱法（ICP-AES）的临床实验室公布的数据不一致。通过比较两种方法的检测限以及两次实验室比对实验的结果，显示了ICP-AES在常规毛发分析中的局限性。从这些数据可以明显看出，已公布的参考区间必须极其谨慎地使用，并且基于ICP-MS技术产生的可靠数据对其进行紧急修订至关重要。
