Korenaga D, Orita H, Maekawa S, Itasaka H, Ikeda T, Sugimachi K
Department of Surgery, Fukuoka City Hospital, Fukuoka, Japan.
Surg Today. 1998;28(8):780-6. doi: 10.1007/s005950050226.
To determine if peritoneal collagen type IV levels could serve as a parameter for predicting metastasis and the subsequent course of disease, the concentration of collagen IV in the peritoneal fluid of 85 patients with adenocarcinoma of the gastrointestinal tract, including 50 with gastric cancer and 35 with colorectal cancer, was measured radioimmunologically. The peritoneal collagen type IV levels were elevated in 13 (26%) of the patients with gastric cancer, in 8 (23%) of those with colorectal cancer, and in none of the control subjects. The mean concentration of collagen type IV in tumors characterized by peritoneal dissemination was significantly higher than that in those without metastasis; however, there were no significant differences in the collagen type IV levels between tumors with and those without liver metastasis, or between those with and those without lymph node metastasis. There was a significant correlation between the peritoneal collagen type IV level and survival time in patients with clinically evident peritoneal dissemination. A positive correlation was also found between collagen type IV and carcinoembryonic antigen levels. In conclusion, the levels of peritoneal collagen type IV provide evidence of peritoneal dissemination, and can aid in the prediction of life expectancy in patients with adenocarcinomas of the gastrointestinal tract.
为了确定腹膜IV型胶原水平是否可作为预测转移及疾病后续进程的一个参数，采用放射免疫法测定了85例胃肠道腺癌患者（包括50例胃癌患者和35例结直肠癌患者）腹膜液中IV型胶原的浓度。13例（26%）胃癌患者、8例（23%）结直肠癌患者的腹膜IV型胶原水平升高，而对照组无一例升高。以腹膜播散为特征的肿瘤中IV型胶原的平均浓度显著高于无转移的肿瘤；然而，有肝转移与无肝转移的肿瘤之间、有淋巴结转移与无淋巴结转移的肿瘤之间，IV型胶原水平无显著差异。在有临床明显腹膜播散的患者中，腹膜IV型胶原水平与生存时间之间存在显著相关性。IV型胶原与癌胚抗原水平之间也呈正相关。总之，腹膜IV型胶原水平为腹膜播散提供了证据，并有助于预测胃肠道腺癌患者的预期寿命。
