Karaayvaz M, Uğraş S, Güler O, Aydin M, Alkan I, Yiğit M F
Department of General Surgery, Y. Yil University Medical School, Van, Turkey.
Surg Today. 1998;28(8):830-3. doi: 10.1007/s005950050235.
We investigated the effectiveness of using an autologous vein graft and stent in the repair of large defects of the common bile duct (CBD) in a canine model. A 3-cm segment of the vena cephalica antibrachii and a 2-cm segment of the CBD were removed from eight healthy mongrel dogs with normal blood biochemistry levels. A stent was passed through the vein segment, and one end was introduced into the proximal end of the CBD while the other end was introduced into the distal end. The venous graft was then sutured to the CBD. A liver biopsy was taken for histopathological examination during laparotomy and relaparotomy. Blood samples were obtained on postoperative days 7, 14, and 20 for biochemical examination. The defect was effectively repaired by the autologous vein graft and stent in 7 dogs, after the exclusion of 1 dog that died of hemorrhage 3 days after the operation. No change in blood biochemistry was observed postoperatively, and no histopathological change in the liver was found in the preoperative or postoperative periods. These findings indicate that the use of an autologous vein graft and stent to repair CBD injuries may be a feasible and alternative method of treatment.
我们在犬类模型中研究了使用自体静脉移植物和支架修复胆总管（CBD）大缺损的有效性。从八只血液生化水平正常的健康杂种犬身上取下3厘米长的前臂头静脉段和2厘米长的胆总管段。将一个支架穿过静脉段，一端插入胆总管近端，另一端插入远端。然后将静脉移植物缝合到胆总管上。在剖腹术和再次剖腹术期间进行肝活检以进行组织病理学检查。在术后第7、14和20天采集血样进行生化检查。排除1只术后3天死于出血的犬后，7只犬的缺损通过自体静脉移植物和支架得到有效修复。术后未观察到血液生化变化，术前和术后肝脏均未发现组织病理学变化。这些发现表明，使用自体静脉移植物和支架修复胆总管损伤可能是一种可行的替代治疗方法。
