Cook C C, Hallwood P M, Thomson A D
Kent Institute of Medicine and Health Sciences, University of Kent at Canterbury, UK.
Alcohol Alcohol. 1998 Jul-Aug;33(4):317-36. doi: 10.1093/oxfordjournals.alcalc.a008400.
Alcohol misuse and alcohol withdrawal are associated with a variety of neuropsychiatric syndromes, some of which are associated with significant morbidity and mortality. B vitamin deficiency is known to contribute to the aetiology of a number of these syndromes, and B vitamin supplementation thus plays a significant part in prophylaxis and treatment. In particular, the Wernicke Korsakoff syndrome (WKS). due to thiamine deficiency, is a common condition in association with alcohol misuse, and is associated with high morbidity and mortality. Nicotinamide deficiency may result in a rarer condition, alcoholic pellagra encephalopathy, which often has a similar clinical presentation to WKS. This review considers the role of B vitamins in the aetiology and treatment of neuropsychiatric syndromes associated with alcohol misuse, with particular emphasis on WKS.
酒精滥用和酒精戒断与多种神经精神综合征相关，其中一些与显著的发病率和死亡率有关。已知B族维生素缺乏会导致其中一些综合征的病因，因此补充B族维生素在预防和治疗中起着重要作用。特别是，由于硫胺素缺乏导致的韦尼克-科尔萨科夫综合征（WKS）是与酒精滥用相关的常见病症，且与高发病率和死亡率相关。烟酰胺缺乏可能导致一种较罕见的病症，即酒精性糙皮病脑病，其临床表现通常与WKS相似。本综述探讨了B族维生素在与酒精滥用相关的神经精神综合征的病因和治疗中的作用，特别强调了WKS。
