Zubaran C, Fernandes J G, Rodnight R
Departamento de Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Postgrad Med J. 1997 Jan;73(855):27-31. doi: 10.1136/pgmj.73.855.27.
Alcohol abuse is one of the most serious problems in public health and the Wernicke-Korsakoff syndrome is one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in treatment planning. Treatment is based on restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article, the literature concerning Wernicke-Korsakoff syndrome is reviewed.
酒精滥用是公共卫生领域最严重的问题之一，韦尼克-科尔萨科夫综合征是酗酒最严重的后果之一。在其不太明显的表现中，病理情况往往未被诊断出来，因此准确的诊断方法是治疗规划中的关键一步。治疗基于硫胺素的补充，尽管这不足以防止大量患者出现心理衰退。该病症的认知影响源自酒精神经毒性、硫胺素缺乏和个人易感性之间的相互作用。本文对有关韦尼克-科尔萨科夫综合征的文献进行了综述。
