Chaurasia S S, Gupta P, Maiti P K, Kar A
Thyroid Research Unit, School of Life Sciences, D. A. University, Indore, India.
J Appl Toxicol. 1998 Jul-Aug;18(4):299-300. doi: 10.1002/(sici)1099-1263(199807/08)18:4<299::aid-jat493>3.0.co;2-j.
The possible involvement of lipid peroxidation (LPO) in the lead-induced inhibition of type I iodothyronine 5'-monodeiodinase activity (5'-D) has been worked out in chicken liver. Lead nitrate (1.5 mg per bird per day) for 30 days increased the lipid peroxidative process with a concomitant decrease in 5'-D activity in chicken liver. Also, a significant decrease in serum triiodothyronine (T3) concentration and an increase in serum thyroxine (T4) concentration were observed. The data suggest that lead-induced inhibition of type I 5'-D activity in chicken liver is mediated through the lipid peroxidative process.
脂质过氧化作用（LPO）可能参与铅诱导的鸡肝中I型碘甲状腺原氨酸5'-单脱碘酶活性（5'-D）抑制作用，这一现象已得到研究。每天给每只鸡喂食1.5毫克硝酸铅，持续30天，鸡肝中的脂质过氧化过程增强，同时5'-D活性降低。此外，还观察到血清三碘甲状腺原氨酸（T3）浓度显著降低，血清甲状腺素（T4）浓度升高。这些数据表明，铅诱导的鸡肝I型5'-D活性抑制是通过脂质过氧化过程介导的。
