Maiti P K, Kar A, Gupta P, Chaurasia S S
Environmental Physiology Laboratory, School of Life Sciences, Devi Ahilya University, Indore, India.
Biochem Biophys Res Commun. 1995 Sep 25;214(3):905-9. doi: 10.1006/bbrc.1995.2372.
The possible involvement of lipid peroxidation (LPO) in the fenvalerate-induced thyroid dysfunction with special reference to type I 5'-monodeiodinase (5'-D) activity has been worked out. Fenvalerate (40, 80 and 120 mg/kg body weight) enhanced LPO in biomembranes of liver and kidney leading to a decrease in membrane integrity. 5'-D activity and serum concentration of triiodothyronine (T3) were reduced by the highest dose. Serum thyroxine (T4) concentration was decreased in all the three fenvalerate-treated groups, indicating the sensitivity of thyroid gland to this pesticide. A marginal increase in T4 concentration in highest dose-treated group compared to that of the lower one supports the view that the monodeiodination of the phenolic ring of T4 is inhibited by fenvalerate. We suggest the possible inactivation of 5'-D by the generated free radicals in pesticide-treated animals.
已研究了脂质过氧化（LPO）在氰戊菊酯诱导的甲状腺功能障碍中的可能作用，特别参考了I型5'-单脱碘酶（5'-D）的活性。氰戊菊酯（40、80和120毫克/千克体重）可增强肝脏和肾脏生物膜中的LPO，导致膜完整性下降。最高剂量可降低5'-D活性和血清三碘甲状腺原氨酸（T3）浓度。在所有三个氰戊菊酯处理组中，血清甲状腺素（T4）浓度均降低，表明甲状腺对这种农药敏感。与较低剂量组相比，最高剂量处理组中T4浓度略有增加，这支持了氰戊菊酯抑制T4酚环单脱碘作用的观点。我们认为在经农药处理的动物中，所产生的自由基可能使5'-D失活。
