Maiti P K, Kar A
Thyroid Research Unit, School of Life Sciences, Devi Ahilya University, Indore, India.
J Appl Toxicol. 1998 Mar-Apr;18(2):125-8. doi: 10.1002/(sici)1099-1263(199803/04)18:2<125::aid-jat483>3.0.co;2-r.
A study on the effect of triiodothyronine (T3) in the regulation of pyrethroid (fenvalerate)-induced thyroid dysfunction and lipid peroxidation was carried out in male mice. Fenvalerate (120 mg kg(-1) body wt. daily for 15 days) administration led to a decrease in the serum concentration of thyroid hormones and the activity of hepatic type I iodothyronine 5'-monodeiodinase (5'D-I) and an increase in the level of lipid peroxidation. The decrease in the activity of hepatic 5'D-I due to the administration of fenvalerate was restored with the administration of T3 (7 microg kg[-1] body wt. on alternate days). The increased level of lipid peroxidation was also ameliorated by T3. However, T3 could not restore the serum concentration of thyroxine (T4), only that of T3. We suggest that the ameliorating role of T3 in the fenvalerate-intoxicated mice could be the result of the lipogenic action of the thyroid hormone, which in turn led to the restoration of 5'D-I activity.
在雄性小鼠中开展了一项关于三碘甲状腺原氨酸（T3）对拟除虫菊酯（氰戊菊酯）诱导的甲状腺功能障碍和脂质过氧化调节作用的研究。给予氰戊菊酯（每天120 mg/kg体重，持续15天）导致甲状腺激素血清浓度降低、肝脏I型碘甲状腺原氨酸5'-单脱碘酶（5'D-I）活性降低以及脂质过氧化水平升高。给予T3（每隔一天7 μg/kg体重）可恢复因给予氰戊菊酯而降低的肝脏5'D-I活性。T3也改善了升高的脂质过氧化水平。然而，T3不能恢复甲状腺素（T4）的血清浓度，只能恢复T3的血清浓度。我们认为，T3对氰戊菊酯中毒小鼠的改善作用可能是甲状腺激素生脂作用的结果，进而导致5'D-I活性恢复。
