Kayyali R, Pannala A S, Khodr H, Hider R C
International Antioxidant Research Centre, Department of Pharmacy, King's College, University of London, UK.
Biochem Pharmacol. 1998 Apr 15;55(8):1327-32. doi: 10.1016/s0006-2952(97)00602-3.
Iron chelators can reduce radical damage inflicted on cells by two mechanisms, either direct scavenging of the radicals or by scavenging loosely bound iron which under aerobic conditions can generate radicals. Frequently it is not possible to distinguish between these two modes of action. 3-Hydroxypyridin-4-ones, in contrast to many iron(III) chelators are poor radical scavengers and therefore have potential in analysing mechanisms involved in biochemical and physiological processes which are centered on radical-induced cell injury.
铁螯合剂可通过两种机制减少对细胞造成的自由基损伤，一是直接清除自由基，二是清除在有氧条件下可产生自由基的松散结合的铁。通常无法区分这两种作用模式。与许多铁（III）螯合剂不同，3-羟基吡啶-4-酮是较差的自由基清除剂，因此在分析以自由基诱导的细胞损伤为中心的生化和生理过程所涉及的机制方面具有潜力。
