Sreejayan N, Rao M N
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Arzneimittelforschung. 1996 Feb;46(2):169-71.
Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.
比较了三种天然姜黄素类化合物（姜黄素（CAS 458-37-7）、去甲氧基姜黄素、双去甲氧基姜黄素）和乙酰姜黄素清除超氧自由基以及与1,1-二苯基-2-苦基肼（DPPH）稳定自由基相互作用的能力。结果表明，姜黄素是最强的超氧自由基清除剂，其次是去甲氧基姜黄素和双去甲氧基姜黄素。乙酰姜黄素没有活性。与DPPH的相互作用显示出类似的活性谱。该研究表明，酚羟基对于自由基清除活性至关重要，而甲氧基的存在进一步增强了活性。
