Selikowitz S M, Olsson C A
Invest Urol. 1976 Sep;14(2):120-3.
Utilizing a low pyridoxine, ethylene glycol-fed rat model, various modes of anticalculus therapy were compared. Prophylactic papillary and parenchymal oxalate stone therapy is most effective with magnesium oxide. Hydrochlorothiazide is next in order as the therapy of choice in this group. A high calcium diet seems to negate the effect of magnesium oxide. Methylene blue, magnesium oxide, and even sodium phosphate, are not as effective as hydrochlorothiazide in the combined prevention and treatment of preformed parencymal calcium oxalate stones. No agent seems to have a profound effect on preformed apical papillary calculi.
利用低吡哆醇、乙二醇喂养的大鼠模型，比较了各种抗结石治疗方式。预防性乳头和实质草酸钙结石治疗中，氧化镁最为有效。氢氯噻嗪是该组治疗的次选药物。高钙饮食似乎会抵消氧化镁的作用。在预防和治疗已形成的实质草酸钙结石方面，亚甲蓝、氧化镁甚至磷酸钠都不如氢氯噻嗪有效。似乎没有药物对已形成的根尖乳头结石有显著影响。
