螺旋蛋白设计

Helical protein design.

作者信息

Schafmeister C E, Stroud R M

机构信息

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

出版信息

Curr Opin Biotechnol. 1998 Aug;9(4):350-3. doi: 10.1016/s0958-1669(98)80006-2.

DOI:10.1016/s0958-1669(98)80006-2

PMID:9720261

Abstract

It is now possible to design small proteins capable of folding into compact structures with well-packed cores. Given the present state of knowledge of protein folding and design, it is possible to extract a set of engineering guidelines that may assist in future de novo protein design.

摘要

现在能够设计出能够折叠成具有紧密堆积核心的紧凑结构的小蛋白质。鉴于目前蛋白质折叠和设计的知识水平，有可能提炼出一套工程指导原则，这可能有助于未来的从头蛋白质设计。