Wikby A, Maxson P, Olsson J, Johansson B, Ferguson F G
Department of Natural Science and Biomedicine, University College of Health Sciences, Jönköping, Sweden.
Mech Ageing Dev. 1998 May 15;102(2-3):187-98. doi: 10.1016/s0047-6374(97)00151-6.
Results from a previous longitudinal study indicated that a combination of high CD8 and low CD4 percentages and poor T cell proliferation in peripheral blood lymphocytes was associated with higher mortality in a subgroup of a sample of very old Swedish individuals. The present study examined whether those results could be confirmed at a subsequent 2-year time interval by investigating if additional individuals from the same original sample had developed the immune profile associated with higher mortality. Subgroups were formed by cluster analysis and similar to our previous results, this follow-up study identified a subgroup of subjects (n = 18) with an immune profile which again included high CD8, low CD4 percentages and poor mitogen response and was associated with higher mortality. Over the 2-year period 12 additional individuals: (1) Developed this immune profile; and (2) Could be identified by changes in their CD4:CD8 ratios which progressively decreased over the study period. These results confirm our original study and indicate that in this very old sample, over a subsequent 2 year period, additional individuals moved into the cluster at risk for higher mortality.
先前一项纵向研究的结果表明，外周血淋巴细胞中CD8百分比高、CD4百分比低以及T细胞增殖能力差的组合与瑞典高龄个体样本中的一个亚组的较高死亡率相关。本研究通过调查来自同一原始样本的其他个体是否出现了与较高死亡率相关的免疫特征，来检验这些结果在随后的2年时间间隔内是否能够得到证实。通过聚类分析形成亚组，与我们之前的结果相似，这项随访研究确定了一个受试者亚组（n = 18），其免疫特征再次包括高CD8、低CD4百分比和较差的有丝分裂原反应，并且与较高死亡率相关。在这2年期间，另外12名个体：（1）出现了这种免疫特征；（2）可以通过其CD4:CD8比值的变化来识别，该比值在研究期间逐渐下降。这些结果证实了我们最初的研究，并表明在这个高龄样本中，在随后的2年期间，更多个体进入了有较高死亡率风险的聚类中。
