Okazaki Y, Rao S, Ito Y, Tateishi T
Mechanical Engineering Laboratory, Agency of Industrial Science and Technology, Ministry of International Trade and Industry, Ibaraki, Japan.
Biomaterials. 1998 Jul;19(13):1197-215. doi: 10.1016/s0142-9612(97)00235-4.
The effects of various metallic ions using various metallic powders on the relative growth ratio of fibroblasts L929 and osteoblasts MC3T3-E1 cells were carried out. Ti, Zr, Sn, Nb and Ta had evidently no effect on the relative growth ratios of cells. Otherwise, Al and V ions exhibit cytotoxicity from a concentration of > or = 0.2 ppm. This Al effect on cells tend to be stronger in medium containing small quantity of V ions (< or = 0.03 ppm). The new Ti-15%Zr-4%Nb-4%Ta-0.2%Pd alloy exhibited a higher corrosion resistance in physiological saline solution. The addition of 0.02%O and 0.05%N to Ti-Zr alloy improved the mechanical properties at room temperature and corrosion fatigue strength. The relative growth ratios for the new Ti alloy plate and the alloy block extraction were unity. Further, the relative growth ratios were almost unity for the new Ti alloy against apatite ceramic pins up to 10(5) wear cycles in Eagle's MEM solution. However, there was a sharp decrease for Ti-6%Al-4%V ELI alloy from 3 x 10(4) wear cycles as V ion was released during wear into the wear test solution since the pH of the Eagle's MEM increases with increasing wear cycles.
研究了使用各种金属粉末的各种金属离子对成纤维细胞L929和成骨细胞MC3T3-E1细胞相对生长率的影响。钛、锆、锡、铌和钽对细胞的相对生长率显然没有影响。否则，铝离子和钒离子在浓度≥0.2 ppm时表现出细胞毒性。在含有少量钒离子（≤0.03 ppm）的培养基中，铝对细胞的这种影响往往更强。新型Ti-15%Zr-4%Nb-4%Ta-0.2%Pd合金在生理盐溶液中表现出更高的耐腐蚀性。向Ti-Zr合金中添加0.02%的氧和0.05%的氮可改善室温下的力学性能和腐蚀疲劳强度。新型钛合金板和合金块提取物的相对生长率均为1。此外，在伊格尔氏MEM溶液中，新型钛合金与磷灰石陶瓷销在高达10⁵次磨损循环时的相对生长率几乎均为1。然而，对于Ti-6%Al-4%V ELI合金，从3×10⁴次磨损循环开始，由于在磨损过程中钒离子释放到磨损试验溶液中，且随着磨损循环次数增加伊格尔氏MEM溶液的pH值升高，其相对生长率急剧下降。
