Parker K L
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Mol Cell Endocrinol. 1998 May 25;140(1-2):59-63. doi: 10.1016/s0303-7207(98)00030-6.
The nuclear hormone receptor family--structurally-related transcriptional regulators that mediate the actions of steroid hormones, thyroid hormone, vitamin D, and retinoids--also includes orphan members that lack known activating ligands. One of these orphan receptors, steroidogenic factor 1 (SF-1), has recently been shown to play key roles in steroidogenic cell function within the adrenal cortex and gonads. SF-1 also contributes to reproductive function at all three levels of the hypothalamic-pituitary-gonadal axis. Key insights into these roles came from analyses of SF-1 knockout mice, which revealed adrenal and gonadal agenesis with consequent male-to-female sex reversal of their internal and external genitalia, impaired gonadotrope function, and agenesis of the ventromedial hypothalamic nucleus. This report reviews the data that have established SF-1 as a critical mediator of endocrine differentiation and function.
核激素受体家族是一类结构相关的转录调节因子，介导类固醇激素、甲状腺激素、维生素D和类视黄醇的作用，其中还包括缺乏已知激活配体的孤儿成员。这些孤儿受体之一，类固醇生成因子1（SF-1），最近已被证明在肾上腺皮质和性腺的类固醇生成细胞功能中起关键作用。SF-1在丘脑-垂体-性腺轴的所有三个水平上也对生殖功能有贡献。对这些作用的关键见解来自对SF-1基因敲除小鼠的分析，这些分析揭示了肾上腺和性腺发育不全，其内外生殖器随之发生从男性到女性的性反转、促性腺激素细胞功能受损以及腹内侧下丘脑核发育不全。本报告回顾了已将SF-1确立为内分泌分化和功能关键介质的数据。
