蛇床子素和花椒毒素系列吡喃香豆素的合成及其细胞毒性活性

Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series.

作者信息

Magiatis P, Melliou E, Skaltsounis A L, Mitaku S, Léonce S, Renard P, Pierré A, Atassi G

机构信息

Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, GR-15771 Athens, Greece, and Institut de Recherche SERVIER, 11 rue des Moulineaux, 92150 Suresnes, France.

出版信息

J Nat Prod. 1998 Aug;61(8):982-6. doi: 10.1021/np9800295.

DOI:10.1021/np9800295

Abstract

The synthesis of known (3-6) and new (7-10 and 14-22) coumarins in the seselin and xanthyletin series is described. The cytotoxic activity of compounds 3-22 was carried out in vitro on L-1210 cells. The most active compounds were 9, 16, 18, and 20 in the seselin series and 10, 17, and 19 in the xanthyletin series. Structure-activity relationships are discussed.

摘要

描述了塞林和黄皮亭系列中已知香豆素（3 - 6）以及新香豆素（7 - 10和14 - 22）的合成。对化合物3 - 22在L - 1210细胞上进行了体外细胞毒性活性测试。塞林系列中活性最强的化合物是9、16、18和20，黄皮亭系列中是10、17和19。讨论了构效关系。

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