Kinane D F
Periodontal Department, Glasgow Dental School, Scotland.
Ann Periodontol. 1998 Jul;3(1):142-50. doi: 10.1902/annals.1998.3.1.142.
Periodontitis and atherosclerosis have complex etiologies, genetic and gender predispositions, and potentially share many risk factors-the most significant of which may be smoking status. These diseases also have many pathogenic mechanisms in common. It is becoming increasingly clear that infections and chronic inflammatory conditions such as periodontitis may influence the atherosclerotic process. The severity and chronicity of periodontal disease provides a rich source of subgingival microbial and host response products and effects over a long time period. The objective of this review is to consider the mechanisms whereby diseases such as periodontitis, which is chronic and Inflammatory In nature and initiated by microbial plaque, can predispose to atherosclerosis. In common with periodontal disease. the pathogenesis of atherosclerosis is not completely understood and both diseases are currently under Intensive investigation. Two main processes in particular are worthy of consideration and may provide the link between these 2 diseases, namely the lipopolysaccharide-related responses and the hyperresponsive monocyte phenomenon. Insufficient experimental evidence exists, however, to further support these hypotheses at present and clearly more research is needed on both of these processes and the interrelationships between both diseases.
牙周炎和动脉粥样硬化有着复杂的病因、遗传和性别易感性，并且可能共享许多风险因素——其中最重要的可能是吸烟状况。这些疾病也有许多共同的致病机制。越来越明显的是，感染和慢性炎症性疾病如牙周炎可能会影响动脉粥样硬化进程。牙周病的严重程度和慢性特征在很长一段时间内提供了丰富的龈下微生物及宿主反应产物和效应来源。这篇综述的目的是探讨诸如牙周炎这类本质上为慢性炎症且由微生物菌斑引发的疾病易导致动脉粥样硬化的机制。与牙周病一样，动脉粥样硬化的发病机制尚未完全明确，这两种疾病目前都在深入研究中。尤其有两个主要过程值得关注，它们可能为这两种疾病之间提供联系，即脂多糖相关反应和单核细胞高反应性现象。然而，目前尚无足够的实验证据进一步支持这些假说，显然对于这两个过程以及两种疾病之间的相互关系还需要更多研究。
