Hsieh J T, Chang H C, Law H S, Hsieh C H, Cheng J T
Department of Urology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Br J Urol. 1998 Aug;82(2):237-40. doi: 10.1046/j.1464-410x.1998.00733.x.
To evaluate the effect of drugs on premature ejaculation using a rat animal model in which the seminal vesicle was electrically stimulated via its lesser splanchnic nerve and changes in the pressure response monitored.
Male Wistar rats (aged 12-14 weeks) were injected intravenously with prazosin and serotonergic agents (serotonin, clomipramine, fluoxetine, imipramine and indatraline) at various concentrations 10 min before electrical nerve stimulation (ENS) of the lesser splanchnic nerve; the initial increase in seminal vesicle pressure in response to ENS was then compared.
The pressure response to ENS was reduced in the presence of prazosin or serotonergic agents. The mean (SEM) maximum inhibition values were 84.1 (8.9%) by fluoxetine at 0.1 mg/kg, 67.9 (8.7)% by prazosin at 0.1 mg/kg, 60.9 (11.0)% by serotonin at 3 mg/kg, 54.9 (4.6)% by clomipramine at 3 mg/kg, 30.0 (11.0)% by imipramine at 0.1 mg/kg, and 20.9 (4.3)% by indatraline at 0.1 mg/kg. From the concentration-response curve, the potency of prazosin was lower than that of fluoxetine, but was higher than that of serotonin or clomipramine.
Like serotonin, fluoxetine and clomipramine can reduce the pressure response of the seminal vesicle to ENS. Among these inhibitory agents, including prazosin, fluoxetine was the most effective and may be valuable for the clinical treatment of ejaculatory dysfunction in man.
利用大鼠动物模型评估药物对早泄的影响，该模型通过内脏小神经对精囊进行电刺激，并监测压力反应的变化。
在对雄性Wistar大鼠（12 - 14周龄）的内脏小神经进行电神经刺激（ENS）前10分钟，静脉注射不同浓度的哌唑嗪和血清素能药物（血清素、氯米帕明、氟西汀、丙咪嗪和茚达曲林）；然后比较精囊对ENS反应的初始压力增加情况。
在存在哌唑嗪或血清素能药物的情况下，对ENS的压力反应降低。氟西汀在0.1 mg/kg时的平均（SEM）最大抑制值为84.1（8.9%），哌唑嗪在0.1 mg/kg时为67.9（8.7）%，血清素在3 mg/kg时为60.9（11.0）%，氯米帕明在3 mg/kg时为54.9（4.6）%，丙咪嗪在0.1 mg/kg时为30.0（11.0）%，茚达曲林在0.1 mg/kg时为20.9（4.3）%。从浓度 - 反应曲线来看，哌唑嗪的效力低于氟西汀，但高于血清素或氯米帕明。
与血清素一样，氟西汀和氯米帕明可降低精囊对ENS的压力反应。在这些抑制剂中，包括哌唑嗪，氟西汀最为有效，可能对人类射精功能障碍的临床治疗有价值。
