Vincent P C, Jennis F, Hilmer R, Fabre S
J Infect Dis. 1976 Aug;134 Suppl:S170-4. doi: 10.1093/infdis/134.supplement_1.s170.
Tobramycin has been shown to be safe and effective when given intravenously in combination antibiotic therapy for infected patients with acute leukemia or other profound pancytopenic states. Tobramycin in combination with one or more antibiotics (usually cephalothin) produced satisfactory clinical results in 21 of 30 episodes of fever. Toxic effects were minimal and were limited to occasional mild thrombophlebitis.
对于患有急性白血病或其他严重全血细胞减少症的感染患者，在联合抗生素治疗中静脉注射妥布霉素已被证明是安全有效的。妥布霉素与一种或多种抗生素（通常是头孢噻吩）联合使用，在30次发热发作中有21次产生了令人满意的临床效果。毒性作用极小，仅限于偶尔出现的轻度血栓性静脉炎。
