Crenshaw C A, Glanges E, Webber C E, Derrick H C, Turner R J, Terrell C J
Surg Gynecol Obstet. 1978 Nov;147(5):713-6.
Antimicrobial therapy should never be used indiscriminately, nor can it take the place of meticulous surgical technique. Appropriate antimicrobial agents administered within the critical time period and in the recommended dosage to achieve adequate serum concentrations effectively reduce the incidence of postoperative wound and other systemic infections. The low incidence of infection and virtual absence of adverse effects strongly suggest that cephalothin-tobramycine combination therapy is a valuable adjunct in emergency surgical procedures.
抗菌治疗绝不应被滥用，也不能取代精细的外科技术。在关键时期内使用适当的抗菌药物并按照推荐剂量给药以达到足够的血清浓度，可有效降低术后伤口感染及其他全身感染的发生率。感染发生率低且几乎没有不良反应，这强烈表明头孢噻吩 - 妥布霉素联合治疗是急诊外科手术中有价值的辅助治疗方法。
