Altucci P, Abbate G F, Alagia I, Leonessa V
J Infect Dis. 1976 Aug;134 Suppl:S182-6. doi: 10.1093/infdis/134.supplement_1.s182.
Twelve patients with acute or chronic pneumonia due mainly to gram-negative bacilli, two patients with pseudomonas endocarditis, and two patients with seratia sepsis were treated with 80-160 mg of tobramycin in two daily doses. Fourteen infected patients with underlying leukemia or lymphoma received this dose of tobramycin combined with cefazolin or penicillin. Most respiratory infections were cured or markedly improved. with eradication or significant reduction in the number of infecting organisms. One case of pseudomonas endocarditis and both cases of serratia sepsis were also cured. Combined treatment with tobramycin and beta-lactam antibiotics resulted in clinical and bacteriological improvement in 50% of systemic immunodepressed patients with sepsis and/or pneumonia.
12例主要由革兰氏阴性杆菌引起的急慢性肺炎患者、2例铜绿假单胞菌性心内膜炎患者和2例沙雷菌败血症患者，接受了每日两次、每次80 - 160毫克妥布霉素的治疗。14例患有潜在白血病或淋巴瘤的感染患者接受了该剂量的妥布霉素联合头孢唑林或青霉素治疗。大多数呼吸道感染得到治愈或明显改善，感染菌数量消除或显著减少。1例铜绿假单胞菌性心内膜炎和2例沙雷菌败血症病例也均被治愈。妥布霉素与β-内酰胺类抗生素联合治疗使50%患有败血症和/或肺炎的全身免疫抑制患者在临床和细菌学方面得到改善。
