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针对慢性病毒感染的治疗性疫苗接种：CD4+和CD8+ T细胞之间合作的重要性。

Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.

作者信息

Zajac A J, Murali-Krishna K, Blattman J N, Ahmed R

机构信息

Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

出版信息

Curr Opin Immunol. 1998 Aug;10(4):444-9. doi: 10.1016/s0952-7915(98)80119-2.

DOI:10.1016/s0952-7915(98)80119-2
PMID:9722921
Abstract

The goal of therapeutic vaccination is to elicit an antiviral immune response within persistently infected individuals and consequently eradicate the infection. CD8+ T cells are potent mediators of viral clearance; however, during chronic infections CD4+ T cell help is required to sustain antiviral CD8+ T cell activity. Therapeutic vaccination should be targeted towards enhancing both CD4+ and CD8+ T cell virus-specific responses.

摘要

治疗性疫苗接种的目标是在持续感染的个体中引发抗病毒免疫反应，从而根除感染。CD8 + T细胞是病毒清除的有效介质；然而，在慢性感染期间，需要CD4 + T细胞的辅助来维持抗病毒CD8 + T细胞的活性。治疗性疫苗接种应旨在增强CD4 +和CD8 + T细胞的病毒特异性反应。

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