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一名年轻患者患慢性复发性皮肤白细胞破碎性血管炎，其EB病毒特异性T细胞反应通过酶联免疫斑点（ELISPOT）检测呈降低，使用伐昔洛韦成功治疗。

Chronic-Relapsing cutaneous leukocytoclastic vasculitis in a young patient with reduced EBV-specific T cell response using enzyme-linked immunospot (ELISPOT) assay successfully treated with Valaciclovir.

作者信息

Foti Caterina, Favoino Elvira, Scarasciulli Maria, Colacicco Anna Maria, Jahantigh Hamidreza, Stufano Angela, Lovreglio Piero, Mascia Paola, Barlusconi Chiara, Perosa Federico, Romita Paolo, Calvario Agata

机构信息

Department of Biomedical Science and Human Oncology, Dermatological Clinic, University of Bari "Aldo Moro", Bari, Italy.

Department of Biomedical Science and Human Oncology (DIMO), Rheumatic and Systemic Autoimmune Diseases Unit, University of Bari Medical School, Bari, Italy.

出版信息

IDCases. 2021 Nov 11;26:e01331. doi: 10.1016/j.idcr.2021.e01331. eCollection 2021.

DOI:10.1016/j.idcr.2021.e01331
PMID:34840952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8605419/
Abstract

Among different pathogens, opportunistic viral infection caused by EBV is particularly relevant. This gammaherpesvirus, belonging to the Herpesviridae family, may complicate the disease course in different clinical settings by inducing pathological EBV pictures in patients with a defective immunologic response. Our report evaluated EBV-specific T cell responses by IFN- γ ELISPOT assay, which revealed defective EBV specific immunological response.

摘要

在不同的病原体中，由EB病毒引起的机会性病毒感染尤为重要。这种γ疱疹病毒属于疱疹病毒科，可能通过在免疫反应缺陷的患者中诱导病理性EB病毒表现，使不同临床环境下的疾病进程复杂化。我们的报告通过IFN-γ ELISPOT试验评估了EB病毒特异性T细胞反应，结果显示存在缺陷的EB病毒特异性免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc7/8605419/64b190003f78/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc7/8605419/64b190003f78/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bc7/8605419/64b190003f78/gr1.jpg

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本文引用的文献

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Epstein-Barr Virus and Systemic Autoimmune Diseases.EB 病毒与系统性自身免疫性疾病。
Front Immunol. 2021 Jan 7;11:587380. doi: 10.3389/fimmu.2020.587380. eCollection 2020.
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Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy.人类疱疹病毒（CMV、HHV-6、HHV-7 和 EBV）在接受化疗的非移植性急性白血病患者中的合并感染。
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原发性活动性EB病毒感染相关的过敏性紫癜：一例报告
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