Hecht N B
Center for Research on Reproduction and Women's Health, Philadelphia, PA, USA.
Bioessays. 1998 Jul;20(7):555-61. doi: 10.1002/(SICI)1521-1878(199807)20:7<555::AID-BIES6>3.0.CO;2-J.
During spermatogenesis, diploid stem cells differentiate, undergo meiosis, and transform into haploid spermatozoa. As this precisely timed series of events proceeds, chromosomal ploidy is reduced and the nucleosomes of the chromatin are replaced by a transcriptionally quiescent protamine-containing nucleus. The premature termination of transcription during the haploid phase of spermatogenesis necessitates an especially prominent role for posttranscriptional regulation in the temporal and spatial expression of many testis-specific proteins and isozymes. In this review article, discussion will focus on novel mechanisms regulating gene expression in mammalian male germ cells from genome to protein.
在精子发生过程中，二倍体干细胞分化、进行减数分裂，并转化为单倍体精子。随着这一系列精确计时的事件推进，染色体倍性降低，染色质的核小体被转录静止的含鱼精蛋白的细胞核所取代。精子发生单倍体阶段转录的过早终止使得转录后调控在许多睾丸特异性蛋白质和同工酶的时空表达中发挥特别突出的作用。在这篇综述文章中，讨论将聚焦于从基因组到蛋白质调控哺乳动物雄性生殖细胞基因表达的新机制。
